Effects of aerobic exercise in patients with CAD prescribed selective versus non-selective beta-blockers on lipid profile and FBS

Document Type : Research Paper


1 University of Guilan

2 Department of Exercise Physiology, University Campus2, University of Guilan, Rasht, Iran

3 Department of Cardiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran


Introduction: Prescribing beta-blockers is very common in treating cardiovascular diseases. The aim of this study was to compare the effects of aerobic exercise in patients with coronary artery disease, prescribed two different types of beta-blockers (selective versus non- selective) on the patient's lipid profile and FBS.
Methods: Sixty patients with coronary artery disease, aged 45-65 years, were compared in two groups of selective (n = 36) versus non-selective (n = 24) users of beta-blockers. Training program consisted of eight weeks of aerobic exercise on treadmill (three sessions per week, about 50 minutes per session, with an intensity of 40% to 60% of the heart rate reserve). Each patient's lipid profile and FBS level, were obtained before the start of the study and after the end of the intervention. Data were then analyzed using statistical methods of repeated mixed ANOVA.
Results: In the selective group, lipid profile and FBS, did not change significantly. In the non-selective group, FBS and triglyceride levels were significantly reduced after the intervention; but HDL, LDL and total cholesterol were not significantly changed (p >0.05).
Conclusion: The results of this study showed that aerobic training in patients with CAD who used non-selective beta-blockers has more positive effects.