Optimal Canceling of the Physiological Tremor for Rehabilitation in Parkinson’s disease

Document Type : Research Paper


1 department of biomedical engineering, university college of Rouzbahan, Sari

2 department of electrical, university college of Rouzbahan, Sari

3 Department of Applied Mathematics, Yazd University, Yazd, Iran

4 sport sciences research institute, Tehran, Iran


Introduction: This study has been conducted to control hand tremor and decrease side-effects due to the high field intensity in advanced Parkinson’s disease through controlling two areas of Basal ganglia at the same time in a closed-loop strategy.
Materials and Methods: In the present research two nuclei of Basal Ganglia (BG) namely subthalamic nucleus (STN) and globus pallidus internal (GPi) were controlled at the same time. Furthermore, to enhance the feasibility of the suggested control strategy, the coefficients of the controller were determined using a hybrid version of the harmony search and cuckoo optimization algorithm (HSCOA). Result: The advantages of this method include decreasing hand tremor and reduction in the applied field and side-effects (such as muscle contraction and speech disorder).
Conclusion: This approach provides an effective strategy to reduce hand tremor and also decrease the delivered high field intensity to the brain and consequently reduce side-effects such as forgetfulness and speech disorders. To ascertain the superior performance of the suggested closed-loop control scheme is examined in terms of robustness against variation of parameters and uncertainties, and also obtained time domain outcomes are compared with the state-of-the-art approaches.