The purpose of this research was to study the effect of caffeine supplement ingestion following a graded interval exercise on ferry fatty acid (FFA), lactate (LA), epinephrine and nor-epinephrine in paraplegic disable individuals. Seven paraplegic disabled individuals participated in this study (age 38.9 ? 2.13 years old, fat percent: 26.53 ? 6.89, weight: 82.33 ? 4.12). Subjects participated in two interval wheelchair trainings with a one-week interval. At first, subjects took part in an interval exercise without the ingestion of caffeine supplement (6 mg per kg) one hour before the exercise (P<0.05). The data of exercise without caffeine ingestion revealed no significant changes in blood FFA, epinephrine and nor-epinephrine but blood lactate significantly increased. After the ingestion of caffeine supplement data showed a significant increase in blood FFA, LA, epinephrine and no significant change in nor-epinephrine. With respect to these findings, one can conclude that caffeine supplement can affect lipid metabolism. Therefore, caffeine can increase body metabolism and can decrease body fat percent of paraplegic disable individuals.